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Welcome to the 19th Annual AMCSI Conference in Atlanta, Georgia!

What is Arthrogryposis Multiplex Congenita (AMC)?

Arthrogryposis multiplex congenita (AMC) is a term used to describe a group of congenital conditions characterized by joint contractures in two or more body areas. While the precise cause may be unknown for some individuals, causes are variable and may include genetic, parental and environmental factors, as well as abnormalities during fetal development. Individuals with AMC have limited joint movement, with or without muscle weakness, in the involved body areas. Contractures vary in distribution and severity, do not progress to previously unaffected joints, but may change over time due to growth and treatment. Spinal deformities may be present at birth or develop throughout childhood and adolescence. Depending on the underlying diagnosis, other body systems such as the respiratory, gastro-intestinal, genito-urinary and central nervous system may be affected. Cognition may be affected if the central nervous system is involved; sensation is usually intact. The impact on mobility, activities of daily living and participation is variable.

Introduction to Arthrogryposis Multiplex Congenita
By Dr. Harolad Van Bosse

Interview with Dr. Harold van Bosse, orthopedic surgeon with Shriners Hospitals for Children-Philadelphia..

Introduction to Arthrogryposis Multiplex Congenita: Part 1 Introduction to Arthrogryposis
Introduction to Arthrogryposis Multiplex Congenita: Part 2, Philosophy of Care
Introduction to Arthrogryposis Multiplex Congenita: Part 3, Treatment Options

Types of Arthrogryposis

The recognized definition of Arthrogryposis Multiplex Congentia (AMC) is a condition that causes congenital contractures of two or more body parts. It is important to remember that AMC is not a diagnosis but is an umbrella term that covers over 300-400 different types of conditions and syndromes.

A simple way to categorize this complex issue is:

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